منابع مشابه
[Natural history of type 1 diabetes].
The natural history of autoimmune type 1 diabetes in children is associated with the appearance of islet autoantibodies early in life, which is influenced by genetic and environmental factors. Once islet autoantibodies have developed, the progression to diabetes in antibody-positive individuals is determined by the age of antibody appearance and by the magnitude of the autoimmunity, in turn rel...
متن کاملNatural History of Type 1 Diabetes
The natural history of autoimmune type 1 diabetes in children is associated with the appearance of islet autoantibodies early in life, which is influenced by genetic and environmental factors. Once islet autoantibodies have developed, the progression to diabetes in antibody-positive individuals is determined by the age of antibody appearance and by the magnitude of the autoimmunity, in turn rel...
متن کاملNatural history and immunopathogenesis of type 1 diabetes.
Type 1 diabetes (T1D) develops in the majority of cases as result of chronic progressive β-cell destruction. This inflammatory damage depends on a selective loss of immune tolerance, that leads to an extensive infiltration of both helper and cytotoxic T-lymphocytes in the pancreatic islets. The autoimmune mechanism is proven by the presence of a pool of autoantibodies (Abs) against structural a...
متن کاملThe pathogenesis and natural history of type 1 diabetes.
The purpose of this article is to provide an overview that summarizes much in the way of our current state of knowledge regarding the pathogenesis and natural history of type 1 diabetes in humans. This information is presented to the reader as a series of seminal historical discoveries that, when advanced through research, transformed our understanding of the roles for the immune system, genes,...
متن کاملNatural History of -Cell Function in Type 1 Diabetes
Despite extensive and ongoing investigations of the immune mechanisms of autoimmune diabetes in humans and animal models, there is much less information about the natural history of insulin secretion before and after the clinical presentation of type 1 diabetes and the factors that may affect its course. Studies of insulin production previously published and from the Diabetes Prevention Trial (...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2005
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.54.suppl_2.s25